Thalidomide-PEG2-C2-NH2 hydrochloride

Catalog No.: A30665
E3 Ligase Ligand-Linker Conjugate
Thalidomide-PEG2-C2-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that features a Thalidomide-derived cereblon ligand combined with a two-unit polyethylene glycol (PEG) linker. This compound is designed for use in proteolysis-targeting chimera (PROTAC) applications, facilitating targeted protein degradation by promoting the interaction between the target protein and the E3 ubiquitin ligase. Its unique structure enables researchers to explore novel therapeutic strategies in cellular and molecular biology studies.
Grouped product items
Size Price Stock Qty
2mg
$20.00
In stock
5mg
$25.00
In stock
10mg
$30.00
In stock
25mg
$40.00
In stock
50mg
$50.00
In stock
100mg
$65.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

Loading distributor info...

Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-PEG2-C2-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that features a Thalidomide-derived cereblon ligand combined with a two-unit polyethylene glycol (PEG) linker. This compound is designed for use in proteolysis-targeting chimera (PROTAC) applications, facilitating targeted protein degradation by promoting the interaction between the target protein and the E3 ubiquitin ligase. Its unique structure enables researchers to explore novel therapeutic strategies in cellular and molecular biology studies.
Product Information
Catalog NumA30665
FormulaC19H25ClN4O6
Molecular Weight440.88
CAS Number2245697-87-2
SMILESO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCN)=O.[H]Cl
SynonymsThalidomide-NH-PEG2-C2-NH2 hydrochloride
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2