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Thalidomide-Piperazine-PEG1-COOH

Catalog No.: A30960
E3 Ligase Ligand-Linker Conjugates
Thalidomide-Piperazine-PEG1-COOH serves as an E3 ligase ligand-linker conjugate, integrating a Thalidomide-derived cereblon ligand with a polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) technology, facilitating targeted protein degradation. It is suitable for research applications aimed at investigating protein regulation and therapeutic strategies in cancer and other diseases.
Thalidomide-Piperazine-PEG1-COOH 2731007-11-5 E3 Ligase Ligand-Linker Conjugates
Grouped product items
Size Price Stock Qty
10mg
$190.00
In stock
25mg
$380.00
In stock
50mg
$535.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-Piperazine-PEG1-COOH serves as an E3 ligase ligand-linker conjugate, integrating a Thalidomide-derived cereblon ligand with a polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC (Proteolysis Targeting Chimeras) technology, facilitating targeted protein degradation. It is suitable for research applications aimed at investigating protein regulation and therapeutic strategies in cancer and other diseases.
Product Information
Catalog NumA30960
FormulaC22H26N4O7
Molecular Weight458.46
CAS Number2731007-11-5
SMILESO=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(N4CCN(CCOCCC(O)=O)CC4)C=C31)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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PROTAC > E3 Ligase Ligand-Linker Conjugate