Thalidomide-Piperazine-PEG2-COOH

Catalog No.: A31247
E3 Ligase Ligand-Linker Conjugates
Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate designed to target cereblon. This compound utilizes a Thalidomide-based ligand and incorporates a PEG2 linker, facilitating the development of PROTAC (Proteolysis Targeting Chimera) technology. It is primarily used in chemical biology research to modulate protein levels through targeted degradation, making it valuable for investigations in cancer and other diseases where protein regulation is essential.
Grouped product items
Size Price Stock Qty
10mg
$190.00
In stock
25mg
$380.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate designed to target cereblon. This compound utilizes a Thalidomide-based ligand and incorporates a PEG2 linker, facilitating the development of PROTAC (Proteolysis Targeting Chimera) technology. It is primarily used in chemical biology research to modulate protein levels through targeted degradation, making it valuable for investigations in cancer and other diseases where protein regulation is essential.
Product Information
Catalog NumA31247
FormulaC24H30N4O8
Molecular Weight502.52
CAS Number2797430-20-5
SMILESO=C1N(C2C(NC(CC2)=O)=O)C(C3=CC(N4CCN(CC4)CCOCCOCCC(O)=O)=CC=C31)=O
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