Thalidomide-Piperazine-PEG2-NH2 is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a PEG2 linker, facilitating targeted protein degradation through the PROTAC technology. This compound is designed to enhance the specificity and efficacy of protein recruitment to the E3 ligase, making it a valuable tool for investigating the mechanisms of targeted ubiquitination and therapeutic intervention in various diseases. Its applications extend to drug discovery, particularly in the development of innovative treatments for conditions reliant on protein homeostasis.
Thalidomide-Piperazine-PEG2-NH2 is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a PEG2 linker, facilitating targeted protein degradation through the PROTAC technology. This compound is designed to enhance the specificity and efficacy of protein recruitment to the E3 ligase, making it a valuable tool for investigating the mechanisms of targeted ubiquitination and therapeutic intervention in various diseases. Its applications extend to drug discovery, particularly in the development of innovative treatments for conditions reliant on protein homeostasis.
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