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Thalidomide-piperazine-tert-butyl formate

Catalog No.: A80425
E3 Ligase Ligand-Linker Conjugate
Thalidomide-piperazine-tert-butyl formate is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand, facilitating targeted protein degradation through the PROTAC (Proteolysis Targeting Chimera) approach. This compound acts by engaging E3 ligases, promoting ubiquitination and subsequent proteasomal degradation of target proteins. It is valuable for research applications involving protein regulation, cellular signaling, and the development of novel therapeutic strategies in various disease contexts.
Thalidomide-piperazine-tert-butyl formate 2222120-27-4 E3 Ligase Ligand-Linker Conjugate
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-piperazine-tert-butyl formate is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand, facilitating targeted protein degradation through the PROTAC (Proteolysis Targeting Chimera) approach. This compound acts by engaging E3 ligases, promoting ubiquitination and subsequent proteasomal degradation of target proteins. It is valuable for research applications involving protein regulation, cellular signaling, and the development of novel therapeutic strategies in various disease contexts.
Product Information
Catalog NumA80425
FormulaC22H28N4O5
Molecular Weight428.49
CAS Number2222120-27-4
SMILESO=C(OC(C)(C)C)N1CCN(C2=CC=C3C(=O)N(CC3=C2)C4C(=O)NC(=O)CC4)CC1
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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PROTAC > E3 Ligase Ligand-Linker Conjugate