Thalidomide-piperidin-C-piperidin hydrochloride is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand. This compound is used in the synthesis of proteolysis-targeting chimeras (PROTACs), which harness the protein degradation machinery to selectively target proteins for ubiquitin-mediated degradation. Its application is pivotal in studying protein regulation and discovery of novel therapeutic strategies in various diseases.
Thalidomide-piperidin-C-piperidin hydrochloride is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand. This compound is used in the synthesis of proteolysis-targeting chimeras (PROTACs), which harness the protein degradation machinery to selectively target proteins for ubiquitin-mediated degradation. Its application is pivotal in studying protein regulation and discovery of novel therapeutic strategies in various diseases.
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