Thalidomide-piperidin-O-piperidin TFA

Catalog No.: A80311
E3 Ligase Ligand-Linker Conjugate
Thalidomide-piperidin-O-piperidin TFA is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTAC (proteolysis-targeting chimeras). This compound features a CRBN-based ligand linked to a piperidine moiety, facilitating targeted protein degradation. It serves as a valuable tool in chemical biology and drug discovery, particularly for studying protein regulation and therapeutic modulation of disease-related proteins.
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5mg
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50mg
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-piperidin-O-piperidin TFA is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTAC (proteolysis-targeting chimeras). This compound features a CRBN-based ligand linked to a piperidine moiety, facilitating targeted protein degradation. It serves as a valuable tool in chemical biology and drug discovery, particularly for studying protein regulation and therapeutic modulation of disease-related proteins.
Product Information
Catalog NumA80311
FormulaC27H30F6N4O9
Molecular Weight668.54
CAS Number2839669-93-9
SMILESO=C1NC(C(CC1)N2C(C3=CC=C(N4CCC(CC4)OC5CCNCC5)C=C3C2=O)=O)=O.O=C(C(F)(F)F)O.O=C(C(F)(F)F)O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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