Thalidomide-piperidin-O-piperidin is an E3 ligase ligand-linker conjugate featuring a CRBN-based ligand and a linker region. This compound is designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras), enabling selective degradation of target proteins via the ubiquitin-proteasome system. Its application in chemical biology facilitates targeted protein modulation and offers insights into protein function and disease mechanisms.
Thalidomide-piperidin-O-piperidin is an E3 ligase ligand-linker conjugate featuring a CRBN-based ligand and a linker region. This compound is designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras), enabling selective degradation of target proteins via the ubiquitin-proteasome system. Its application in chemical biology facilitates targeted protein modulation and offers insights into protein function and disease mechanisms.
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