Thalidomide-piperidine-O-azetidine-boc

Catalog No.: A31636
E3 Ligase Ligand-Linker Conjugate
Thalidomide-piperidine-O-azetidine-boc is a conjugate designed as an E3 ubiquitin ligase ligand-linker. This compound facilitates the synthesis of complete PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation in various biological research applications. It serves as a valuable tool for studying protein function and modulation, particularly in therapeutic contexts.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-piperidine-O-azetidine-boc is a conjugate designed as an E3 ubiquitin ligase ligand-linker. This compound facilitates the synthesis of complete PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation in various biological research applications. It serves as a valuable tool for studying protein function and modulation, particularly in therapeutic contexts.
Product Information
Catalog NumA31636
FormulaC26H32N4O7
Molecular Weight512.55
CAS Number2991611-55-1
SMILESO=C(N1CC(C1)OC2CCN(CC2)C3=CC=C4C(N(C5C(NC(CC5)=O)=O)C(C4=C3)=O)=O)OC(C)(C)C
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