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Thalidomide-propargyl-NHCH3

Catalog No.: A80366
E3 Ligase Ligand-Linker Conjugate
Thalidomide-propargyl-NHCH3 is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand with a propargyl linker. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs) by promoting targeted protein degradation. Its applications include advancing research on protein regulation and therapeutic development in various diseases.
Thalidomide-propargyl-NHCH3 1216805-74-1 E3 Ligase Ligand-Linker Conjugate
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-propargyl-NHCH3 is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand with a propargyl linker. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs) by promoting targeted protein degradation. Its applications include advancing research on protein regulation and therapeutic development in various diseases.
Product Information
Catalog NumA80366
FormulaC17H15N3O4
Molecular Weight325.32
CAS Number1216805-74-1
SMILESO=C1NC(=O)C(N2C(=O)C3=CC=C(C#CCNC)C=C3C2=O)CC1
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PROTAC > E3 Ligase Ligand-Linker Conjugate