THZ1

Catalog No.: A14192

CDK7 Inhibitor

THZ1

THZ1 Chemical Structure

CAS NO. 1604810-83-4

THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
25 mg
$220.00
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Biological Activity

THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM
In vitro (25°C) DMSO 96 mg/mL (150.24 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.67 mL 88.33 mL 176.66 mL
0.5 mM 3.53 mL 17.67 mL 35.33 mL
1 mM 1.77 mL 8.83 mL 17.67 mL
5 mM 0.35 mL 1.77 mL 3.53 mL

*The above data is based on the productmolecular weight 566.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14192
Actions Inhibitor
CAS No. 1604810-83-4
Formula C31H28ClN7O2
M. Wt 566.05
Purity >98%
Synonyms THZ-1,THZ 1
SMILES CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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