THZ1

Catalog No.: A14192
CDK7 Inhibitor
THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM
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Product Name Price Stock Qty
THZ1 5mg
Special Price $56.00 Regular Price $70.00
In stock
THZ1 10mg
Special Price $96.00 Regular Price $120.00
In stock
THZ1 25mg
Special Price $176.00 Regular Price $220.00
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's THZ1 has been cited by 1 publications
  • Guowang Li, .et al. , Life Sci Alliance, 2023, Apr 3;6(6):e202201854 PMID: 37012048
  • Biological Activity
    Discription THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM
    Targets
    Target Value
    Product Information
    Catalog Num A14192
    Formula C31H28ClN7O2
    Molecular Weight 566.05
    CAS Number 1604810-83-4
    SMILES CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
    Synonyms THZ-1,THZ 1
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 96 mg/mL (150.24 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+45% PEG 300+ddH2O 3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.67 mL 88.33 mL 176.66 mL
    0.5 mM 3.53 mL 17.67 mL 35.33 mL
    1 mM 1.77 mL 8.83 mL 17.67 mL
    5 mM 0.35 mL 1.77 mL 3.53 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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