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Biological Activity
THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. THZ531 irreversibly targets a cysteine located outside the kinase domain. THZ531 causes a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II.
| In vitro | DMSO | 95 mg/mL (170.22 mM) | |
| Water | Insoluble | ||
| Ethanol | 95 mg/mL (170.22 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.92 mL | 89.59 mL | 179.19 mL |
| 0.5 mM | 3.58 mL | 17.92 mL | 35.84 mL |
| 1 mM | 1.79 mL | 8.96 mL | 17.92 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
*The above data is based on the productmolecular weight 558.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17036 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1702809-17-3 |
| Formula | C30H32ClN7O2 |
| M. Wt | 558.08 |
| Purity | >98% |
| Synonyms | THZ-531, THZ 531 |
| SMILES | O=C(NC1=CC=C(C(N2C[[email protected]](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C=C1)/C=C/CN(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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