THZ531

Catalog No.: A17036

CDK12 and CDK13 covalent inhibitor

THZ531

THZ531 Chemical Structure

CAS NO. 1702809-17-3

THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. THZ531 irreversibly targets a cysteine located outside the kinase domain. THZ531 causes a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$180.00
50 mg
$620.00
100 mg
$1,080.00
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Biological Activity

THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. THZ531 irreversibly targets a cysteine located outside the kinase domain. THZ531 causes a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.92 mL 89.59 mL 179.19 mL
0.5 mM 3.58 mL 17.92 mL 35.84 mL
1 mM 1.79 mL 8.96 mL 17.92 mL
5 mM 0.36 mL 1.79 mL 3.58 mL

*The above data is based on the productmolecular weight 558.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17036
Actions Inhibitor
M. Wt 558.08
Formula C30H32ClN7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1702809-17-3
Synonyms THZ-531, THZ 531
SMILES O=C(NC1=CC=C(C(N2C[[email protected]](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C=C1)/C=C/CN(C)C

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