THZ531

Catalog No.: A17036

CDK12 and CDK13 covalent inhibitor

THZ531

THZ531 Chemical Structure

CAS NO. 1702809-17-3

THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. THZ531 irreversibly targets a cysteine located outside the kinase domain. THZ531 causes a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$180.00
50 mg
$620.00
100 mg
$1,080.00
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Biological Activity

THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. THZ531 irreversibly targets a cysteine located outside the kinase domain. THZ531 causes a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II.
In vitro DMSO 95 mg/mL (170.22 mM)
Water Insoluble
Ethanol 95 mg/mL (170.22 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.92 mL 89.59 mL 179.19 mL
0.5 mM 3.58 mL 17.92 mL 35.84 mL
1 mM 1.79 mL 8.96 mL 17.92 mL
5 mM 0.36 mL 1.79 mL 3.58 mL

*The above data is based on the productmolecular weight 558.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17036
Actions Inhibitor
CAS No. 1702809-17-3
Formula C30H32ClN7O2
M. Wt 558.08
Purity >98%
Synonyms THZ-531, THZ 531
SMILES O=C(NC1=CC=C(C(N2C[[email protected]](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C=C1)/C=C/CN(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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