Tiagabine hydrochloride hydrate is a potent and selective inhibitor of GABA uptake, primarily targeting the GABA receptor. It demonstrates significant anticonvulsant activity, with IC50 values of 67 nM in synaptosomes, 446 nM in neurons, and 182 nM in glial cells for [3H]GABA uptake. This compound is widely utilized in research focused on epilepsy and related neurological disorders.
Tiagabine hydrochloride hydrate is a potent and selective inhibitor of GABA uptake, primarily targeting the GABA receptor. It demonstrates significant anticonvulsant activity, with IC50 values of 67 nM in synaptosomes, 446 nM in neurons, and 182 nM in glial cells for [3H]GABA uptake. This compound is widely utilized in research focused on epilepsy and related neurological disorders.
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