TIP 39, Tuberoinfundibular Neuropeptide, is an endogenous agonist of the PTH2 receptor, exhibiting antihypertensive effects. This peptide selectively activates the PTH2 receptor without affecting the PTH1 receptor, leading to increased cAMP production, adenylate cyclase activation, and enhanced intracellular calcium mobilization. TIP 39 is conserved across humans, mice, and rats, making it a valuable tool for research into nociception and inflammation-related pain mechanisms.
TIP 39, Tuberoinfundibular Neuropeptide, is an endogenous agonist of the PTH2 receptor, exhibiting antihypertensive effects. This peptide selectively activates the PTH2 receptor without affecting the PTH1 receptor, leading to increased cAMP production, adenylate cyclase activation, and enhanced intracellular calcium mobilization. TIP 39 is conserved across humans, mice, and rats, making it a valuable tool for research into nociception and inflammation-related pain mechanisms.
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