Tityustoxin-Kα

Catalog No.: A68118
Potassium Channel Inhibitor
Tityustoxin-Kα is a potent inhibitor of voltage-gated potassium channels. It exhibits a dose-dependent blockade of the sustained outward current in cultured hippocampal neurons, making it a valuable tool for researching neuronal excitability and synaptic transmission. Its application extends to studies on channel physiology and the mechanisms underlying neurotoxicity.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTityustoxin-Kα is a potent inhibitor of voltage-gated potassium channels. It exhibits a dose-dependent blockade of the sustained outward current in cultured hippocampal neurons, making it a valuable tool for researching neuronal excitability and synaptic transmission. Its application extends to studies on channel physiology and the mechanisms underlying neurotoxicity.
Product Information
Catalog NumA68118
FormulaC168H275N49O46S7
Molecular Weight3941.74
CAS Number152618-71-8
SequenceVal-Phe-Ile-Asn-Ala-Lys-Cys-Arg-Gly-Ser-Pro-Glu-Cys-Leu-Pro-Lys-Cys-Lys-Glu-Ala-Ile-Gly-Lys-Ala-Ala-Gly-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro (Disulfide bridge: Cys7-Cys28, Cys13-Cys33, Cys17-Cys35)
Sequence shorteningVFINAKCRGSPECLPKCKEAIGKAAGKCMNGKCKCYP (Disulfide bridge: Cys7-Cys28, Cys13-Cys33, Cys17-Cys35)
SynonymsTsTx-Kα
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