TL033 TFA is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a linker that connects bioactive small molecule toxins, facilitating targeted delivery of cytotoxic agents. When conjugated with the Sacituzumab antibody (anti-Trop-2), TL033 TFA enables the synthesis of BT001021, which demonstrates potent anti-cancer activity across various malignancies, including breast cancer, non-small cell lung cancer (NSCLC), and gastric cancer.
TL033 TFA is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a linker that connects bioactive small molecule toxins, facilitating targeted delivery of cytotoxic agents. When conjugated with the Sacituzumab antibody (anti-Trop-2), TL033 TFA enables the synthesis of BT001021, which demonstrates potent anti-cancer activity across various malignancies, including breast cancer, non-small cell lung cancer (NSCLC), and gastric cancer.
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