TL13-112

Name: TL13-112
Brand: Adooq Bioscience
SKU: A23958
Rating: 5 (288 reviews)

Catalog No.: A23958

PROTAC ALK Degrader

TL13-112 is a potent and selective PROTAC degrader targeting ALK, with an IC₅₀ of 0.14 nM for ALK inhibition. In addition to ALK, TL13-112 also induces degradation of Aurora A (IC₅₀: 8550 nM), FER (42.4 nM), PTK2 (25.4 nM), and RPS6KA1 (677 nM), supporting its utility in kinase signaling and cancer research.

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TL13-112 2229037-19-6 PROTAC ALK Degrader

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Grouped product items
Size	Price	Stock
5mg	$225.00	In stock
10mg	$388.00	In stock
50mg	$1,150.00	In stock
100mg	$2,250.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	TL13-112 is a potent and selective PROTAC degrader targeting ALK, with an IC₅₀ of 0.14 nM for ALK inhibition. In addition to ALK, TL13-112 also induces degradation of Aurora A (IC₅₀: 8550 nM), FER (42.4 nM), PTK2 (25.4 nM), and RPS6KA1 (677 nM), supporting its utility in kinase signaling and cancer research.

Product Information

Catalog Num	A23958
Formula	C49H60ClN9O10S
Molecular Weight	1002.57
CAS Number	2229037-19-6
SMILES	O=C(NCCOCCOCCN1CCC(C2=CC(OC(C)C)=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C=C2C)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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