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TLC388

Catalog No.: A57197
Camptothecin Analog
TLC388 is a novel camptothecin analog targeting topoisomerase I, exhibiting potential antitumor activity in metastatic neuroendocrine carcinoma (NEC). Its unique chemical structure enhances its efficacy in disrupting DNA replication and transcription processes. This compound is valuable for research applications focused on understanding camptothecin derivatives in cancer therapy and exploring mechanisms of drug resistance in NECs.
TLC388 1432468-79-5 Camptothecin Analog
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Size Price Stock Qty
25mg
$1,275.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTLC388 is a novel camptothecin analog targeting topoisomerase I, exhibiting potential antitumor activity in metastatic neuroendocrine carcinoma (NEC). Its unique chemical structure enhances its efficacy in disrupting DNA replication and transcription processes. This compound is valuable for research applications focused on understanding camptothecin derivatives in cancer therapy and exploring mechanisms of drug resistance in NECs.
Product Information
Catalog NumA57197
FormulaC39H30N8O15
Molecular Weight850.70
CAS Number1432468-79-5
SMILESCC(O/N=C1C2=C(C3=C/1C=C([N+]([O-])=O)C=C3[N+]([O-])=O)C([N+]([O-])=O)=CC([N+]([O-])=O)=C2)C(O[C@](C4=C(CO5)C(N6CC7=CC8=C(CN(C)C)C(O)=CC=C8N=C7C6=C4)=O)(CC)C5=O)=O
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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DNA Damage > Topoisomerase