TLR7/8/9 Antagonist 2 is a potent orally active inhibitor targeting Toll-like receptors 7, 8, and 9. It demonstrates significant inhibitory effects on HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9, with IC50 values of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. This compound exhibits high bioavailability in vivo, making it a valuable tool for investigating auto-inflammatory diseases, including systemic lupus erythematosus and lupus nephritis.
TLR7/8/9 Antagonist 2 is a potent orally active inhibitor targeting Toll-like receptors 7, 8, and 9. It demonstrates significant inhibitory effects on HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9, with IC50 values of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. This compound exhibits high bioavailability in vivo, making it a valuable tool for investigating auto-inflammatory diseases, including systemic lupus erythematosus and lupus nephritis.
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