TLR7/8 Agonist 13 is a potent dual agonist targeting Toll-like receptors 7 and 8, with lowest effective concentrations (LEC) of 1.6 μM for both human receptors. This compound demonstrates significant biological activity by stimulating human peripheral blood mononuclear cells (hPBMCs) at an LEC of 0.5 μM, leading to the induction of endogenous interferon-alpha (IFNα). In preclinical models, TLR7/8 Agonist 13 enhances the activation of myeloid dendritic cells and monocytes towards a TH1 phenotype and reduces viral load as well as Hepatitis B virus (HBV) surface antigen expression. It serves as a valuable tool for investigating immune responses in HBV-related research.
TLR7/8 Agonist 13 is a potent dual agonist targeting Toll-like receptors 7 and 8, with lowest effective concentrations (LEC) of 1.6 μM for both human receptors. This compound demonstrates significant biological activity by stimulating human peripheral blood mononuclear cells (hPBMCs) at an LEC of 0.5 μM, leading to the induction of endogenous interferon-alpha (IFNα). In preclinical models, TLR7/8 Agonist 13 enhances the activation of myeloid dendritic cells and monocytes towards a TH1 phenotype and reduces viral load as well as Hepatitis B virus (HBV) surface antigen expression. It serves as a valuable tool for investigating immune responses in HBV-related research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
