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Biological Activity
TNP 470 is an analog of Fumagillin that displays potent antiangiogenic activity in vitro. Shown to inhibit MetAP-2 (methionine aminopeptidase type II ).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.88 mL | 124.42 mL | 248.83 mL |
| 0.5 mM | 4.98 mL | 24.88 mL | 49.77 mL |
| 1 mM | 2.49 mL | 12.44 mL | 24.88 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
*The above data is based on the productmolecular weight 401.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14014 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 129298-91-5 |
| Formula | C19H28CINO6 |
| M. Wt | 401.88 |
| Purity | >98% |
| Synonyms | TNP470, TNP 470, O-(Chloroacetyl-carbamoyl) Fumagillol, NSC 642492, AGM-1470 |
| SMILES | CC(=CC[C@H]1[C@](O1)(C)C2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)NC(=O)CCl)OC)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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