Catalog No.: A20966
COMT inhibitor
Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor.
Grouped product items
Product Name Price Stock Qty
Tolcapone 10mg
In stock
Tolcapone 25mg
In stock
Tolcapone 50mg
In stock
Tolcapone 100mg
In stock

Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor.
Chemical Information
Catalog Num A20966
Formula C14H11NO5
Molecular Weight 273.24
CAS Number 134308-13-7
SMILES O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=CC=C(C)C=C2
Synonyms Ro 40-7592, Ro40-7592, Ro-40-7592

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

In vitro DMSO 53 mg/mL (193.96 mM)
Water Insoluble
Ethanol 53 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.6 mL 182.99 mL 365.98 mL
0.5 mM 7.32 mL 36.6 mL 73.2 mL
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
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