Catalog No.: A20966

COMT inhibitor


Tolcapone Chemical Structure

CAS NO. 134308-13-7

Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor.

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Biological Activity

Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor.
In vitro DMSO 53 mg/mL (193.96 mM)
Water Insoluble
Ethanol 53 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.6 mL 182.99 mL 365.98 mL
0.5 mM 7.32 mL 36.6 mL 73.2 mL
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL

*The above data is based on the productmolecular weight 273.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20966
Actions Inhibitor
CAS No. 134308-13-7
Formula C14H11NO5
M. Wt 273.24
Purity >98%
Synonyms Ro 40-7592, Ro40-7592, Ro-40-7592
SMILES O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=CC=C(C)C=C2

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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