Topoisomerase I-IN-19

Catalog No.: A57157
Topoisomerase I Inhibitor
Topoisomerase I-IN-19 is a potent inhibitor of Topoisomerase I, a critical enzyme involved in DNA replication and transcription. This compound facilitates the study of Topoisomerase I-mediated diseases, particularly in cancer research, by allowing for the evaluation of cell growth, apoptosis, and the therapeutic potential of Topoisomerase I inhibition. Its efficacy in modulating Topoisomerase I activity makes it a valuable tool for mechanistic studies and drug development in oncology.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTopoisomerase I-IN-19 is a potent inhibitor of Topoisomerase I, a critical enzyme involved in DNA replication and transcription. This compound facilitates the study of Topoisomerase I-mediated diseases, particularly in cancer research, by allowing for the evaluation of cell growth, apoptosis, and the therapeutic potential of Topoisomerase I inhibition. Its efficacy in modulating Topoisomerase I activity makes it a valuable tool for mechanistic studies and drug development in oncology.
Product Information
Catalog NumA57157
FormulaC23H21N3O5
Molecular Weight419.43
CAS Number3080647-12-4
SMILESO=C1C2=C(CN3C2=CC4=C(COC([C@]4(O)CC)=O)C3=O)N5C6=C(CCC5)C(N)=CC=C61
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