Topoisomerase inhibitor 6

Catalog No.: A49852
DNA Gyrase/Topoisomerase IV Inhibitor
Topoisomerase Inhibitor 6 is a dual irreversible inhibitor targeting DNA gyrase and topoisomerase IV, demonstrating a minimum inhibitory concentration (MIC) of 0.06 μg/mL against fluoroquinolone-resistant Staphylococcus aureus. This compound functions by obstructing the DNA strand break-reunion process, thereby causing lethal DNA damage. It holds potential for the study of Gram-positive bacterial infections, including those caused by S. aureus and Streptococcus pneumoniae.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTopoisomerase Inhibitor 6 is a dual irreversible inhibitor targeting DNA gyrase and topoisomerase IV, demonstrating a minimum inhibitory concentration (MIC) of 0.06 μg/mL against fluoroquinolone-resistant Staphylococcus aureus. This compound functions by obstructing the DNA strand break-reunion process, thereby causing lethal DNA damage. It holds potential for the study of Gram-positive bacterial infections, including those caused by S. aureus and Streptococcus pneumoniae.
Product Information
Catalog NumA49852
FormulaC20H22ClFN4O2
Molecular Weight404.87
CAS Number2987726-03-2
SMILESC[C@H](N)[C@H]1CN(C2=C(Cl)C(N(C3CC3)C(C4=C5OC(C)=N4)=O)=C5C=C2F)CC1
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