Topoisomerase IV inhibitor 1 is a selective inhibitor of DNA topoisomerase IV, exhibiting an IC50 value of 0.23 μM, which highlights its potent activity. It additionally demonstrates inhibitory effects on DNA gyrase with an IC50 of 0.43 μM. This compound showcases significant antibacterial properties, with minimum inhibitory concentrations (MICs) of 0.972 μM against Staphylococcus aureus Newman and 0.608 μM against Escherichia coli ATCC8739. It is ideal for research applications focused on bacterial topoisomerase mechanisms and the development of novel antimicrobial agents.
Topoisomerase IV inhibitor 1 is a selective inhibitor of DNA topoisomerase IV, exhibiting an IC50 value of 0.23 μM, which highlights its potent activity. It additionally demonstrates inhibitory effects on DNA gyrase with an IC50 of 0.43 μM. This compound showcases significant antibacterial properties, with minimum inhibitory concentrations (MICs) of 0.972 μM against Staphylococcus aureus Newman and 0.608 μM against Escherichia coli ATCC8739. It is ideal for research applications focused on bacterial topoisomerase mechanisms and the development of novel antimicrobial agents.
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