Torin 1

Catalog No.: A11587

mTOR inhibitor

Torin 1

Torin 1 Chemical Structure

CAS NO. 1222998-36-8

Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Kowalsky AH, .et al. The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation, J Biol Chem, 2020, Feb 14;295(7):1769-1780 PMID: 31915252
  • Ashyad Rayhan, .et al. Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function, Biol Open, 2018, Jan 15; 7(1): bio031302 PMID: 29343513
  • Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422

Biological Activity

Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
Target Value
mTORC1IC50: 2nM
mTORIC50: 4.32nM
DNA-PKIC50: 6.34nM
mTORC2IC50: 10nM
p110γIC50: 171nM
C2αIC50: 176nM
p110α/p85αIC50: 250nM
hVPS34IC50: 533nM
C2βIC50: 549nM
p110δ/p85αIC50: 564nM
PI4KβIC50: 6680nM
PI4KαIC50: >10μM
In vitro (25°C) DMSO 2 mg/mL (3.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.46 mL 82.29 mL 164.58 mL
0.5 mM 3.29 mL 16.46 mL 32.92 mL
1 mM 1.65 mL 8.23 mL 16.46 mL
5 mM 0.33 mL 1.65 mL 3.29 mL

*The above data is based on the productmolecular weight 607.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11587
Actions Inhibitor
M. Wt 607.62
Formula C35H28F3N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1222998-36-8
Synonyms Torin1

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