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- Andromachi Lambrianidou, .et al. mTORC2 deploys the mRNA binding protein IGF2BP1 to regulate c-MYC expression and promote cell survival, Cell Signal, 2021, Apr;80:109912 PMID: 33388443
- Kowalsky AH, .et al. The GATOR2?CmTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation, J Biol Chem, 2020, Feb 14;295(7):1769-1780 PMID: 31915252
- Ashyad Rayhan, .et al. Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function, Biol Open, 2018, Jan 15; 7(1): bio031302 PMID: 29343513
- Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
Biological Activity
Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
Targets
| Target | Value |
|---|---|
| mTORC1 | IC50: 2nM |
| mTOR | IC50: 4.32nM |
| DNA-PK | IC50: 6.34nM |
| mTORC2 | IC50: 10nM |
| p110γ | IC50: 171nM |
| C2α | IC50: 176nM |
| p110α/p85α | IC50: 250nM |
| hVPS34 | IC50: 533nM |
| C2β | IC50: 549nM |
| p110δ/p85α | IC50: 564nM |
| PI4Kβ | IC50: 6680nM |
| PI4Kα | IC50: >10μM |
| In vitro | DMSO | 2 mg/mL (3.29 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.46 mL | 82.29 mL | 164.58 mL |
| 0.5 mM | 3.29 mL | 16.46 mL | 32.92 mL |
| 1 mM | 1.65 mL | 8.23 mL | 16.46 mL |
| 5 mM | 0.33 mL | 1.65 mL | 3.29 mL |
*The above data is based on the productmolecular weight 607.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11587 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1222998-36-8 |
| Formula | C35H28F3N5O2 |
| M. Wt | 607.62 |
| Purity | >98% |
| Synonyms | Torin1 |
| SMILES | CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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