TPA-023B is an orally active partial agonist at the GABAA receptor α2 and α3 subtypes, with affinities of 0.73 nM and 2 nM, respectively, while acting as an antagonist at the α1 subtype with a Ki of 1.8 nM. This compound exhibits non-sedating anxiolytic-like properties, making it a valuable tool for research into anxiety disorders and GABAergic signaling. Its selective modulation of specific GABA receptor subtypes allows for nuanced studies on neuropharmacological effects.
TPA-023B is an orally active partial agonist at the GABAA receptor α2 and α3 subtypes, with affinities of 0.73 nM and 2 nM, respectively, while acting as an antagonist at the α1 subtype with a Ki of 1.8 nM. This compound exhibits non-sedating anxiolytic-like properties, making it a valuable tool for research into anxiety disorders and GABAergic signaling. Its selective modulation of specific GABA receptor subtypes allows for nuanced studies on neuropharmacological effects.
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