TPBM is a selective estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for the 17β-estradiol (E2)-ERα complex. This compound effectively diminishes the recruitment of E2·ERα to endogenous estrogen-responsive genes. Additionally, TPBM demonstrates the capacity to inhibit E2-dependent proliferation of ERα-positive cancer cells, exhibiting an IC50 of 5 μM. Notably, TPBM is non-toxic to normal cells and does not interfere with estrogen-independent cell growth, making it a valuable tool for research in hormone-responsive signaling pathways and cancer biology.
TPBM is a selective estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for the 17β-estradiol (E2)-ERα complex. This compound effectively diminishes the recruitment of E2·ERα to endogenous estrogen-responsive genes. Additionally, TPBM demonstrates the capacity to inhibit E2-dependent proliferation of ERα-positive cancer cells, exhibiting an IC50 of 5 μM. Notably, TPBM is non-toxic to normal cells and does not interfere with estrogen-independent cell growth, making it a valuable tool for research in hormone-responsive signaling pathways and cancer biology.
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