TRAM-34

Catalog No.: A12783

Potassium Channel Blocker

TRAM-34

TRAM-34 Chemical Structure

CAS NO. 289905-88-0

TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $60.00

Special Price $54.00

25 mg

Regular Price: $130.00

Special Price $117.00

50 mg

Regular Price: $240.00

Special Price $216.00

100 mg

Regular Price: $380.00

Special Price $342.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
Targets
IKCa1 (KCa3.1)
20 nM(Kd)
In vitro (25°C) DMSO 0.4 mg/mL (1.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29 mL 144.99 mL 289.99 mL
0.5 mM 5.8 mL 29 mL 58 mL
1 mM 2.9 mL 14.5 mL 29 mL
5 mM 0.58 mL 2.9 mL 5.8 mL

*The above data is based on the productmolecular weight 344.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A12783
Actions Blocker
M. Wt 344.84
Formula C22H17ClN2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 289905-88-0
Synonyms TRAM34, TRAM 34
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4

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