TRAM-34

Catalog No.: A12783
Potassium Channel Blocker
TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
Grouped product items
Size Price Stock Qty
5mg
$30.00
In stock
10mg
$35.00
In stock
25mg
$75.00
In stock
50mg
$130.00
In stock
100mg
$190.00
In stock
200mg
$245.00
In stock
500mg
$420.00
In stock
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Important Notice: For research use only. We do not sell to patients.

Adooq Products cited in reputable paper
Adooq's TRAM-34 has been cited by 2 publications
  • Samuel Drinkall, .et al. , Glia, 2022, Jul;70(7):1301-1316 PMID: 35353387
  • Cheong Hoon Seo, .et al. , Transl Res, 2021, Apr 24 PMID: 33905948
  • Biological Activity
    Discription TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A12783
    Formula C22H17ClN2
    Molecular Weight 344.84
    CAS Number 289905-88-0
    SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4
    Synonyms TRAM34, TRAM 34
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 0.36 mg/mL (1.04 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+corn oil 1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 29 mL 144.99 mL 289.99 mL
    0.5 mM 5.8 mL 29 mL 58 mL
    1 mM 2.9 mL 14.5 mL 29 mL
    5 mM 0.58 mL 2.9 mL 5.8 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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