TRAM-39 is a selective inhibitor of intermediate conductance Ca2+-activated K+ (IKCa) channels, specifically targeting the KCa3.1 channel with an IC50 value of 60 nM. This compound is valuable for investigating various neurological conditions, including ataxia, epilepsy, memory disorders, schizophrenia, and Parkinson’s disease. Its ability to modulate IKCa channels makes it a useful tool for studying calcium signaling pathways and their implications in related pathologies.
TRAM-39 is a selective inhibitor of intermediate conductance Ca2+-activated K+ (IKCa) channels, specifically targeting the KCa3.1 channel with an IC50 value of 60 nM. This compound is valuable for investigating various neurological conditions, including ataxia, epilepsy, memory disorders, schizophrenia, and Parkinson’s disease. Its ability to modulate IKCa channels makes it a useful tool for studying calcium signaling pathways and their implications in related pathologies.
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