Transthyretin-IN-3 is a benzofuran analogue that selectively inhibits transthyretin (TTR) by binding to its thyroxine binding site. This compound effectively disrupts amyloid aggregation, demonstrating an IC50 value of 5.0±0.2 μM. By preventing the dissociation of TTR tetramers into unstable monomers, Transthyretin-IN-3 shows potential in research applications related to amyloid-related diseases.
Transthyretin-IN-3 is a benzofuran analogue that selectively inhibits transthyretin (TTR) by binding to its thyroxine binding site. This compound effectively disrupts amyloid aggregation, demonstrating an IC50 value of 5.0±0.2 μM. By preventing the dissociation of TTR tetramers into unstable monomers, Transthyretin-IN-3 shows potential in research applications related to amyloid-related diseases.
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