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TRAP-14 amide

Catalog No.: A57548
PAR Activating Peptide
TRAP-14 amide is a PAR-activating peptide that acts as an agonist with an EC50 of 24 μM. It significantly promotes platelet aggregation through ADP- and MMP-2-dependent pathways, demonstrating resistance to inhibition by Aspirin. Additionally, TRAP-14 amide enhances the surface expression of glycoprotein Ib and GPIIb/IIIa while facilitating ADP release, making it a valuable tool for research into platelet function and thrombus formation.
TRAP-14 amide 141923-36-6 PAR Activating Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTRAP-14 amide is a PAR-activating peptide that acts as an agonist with an EC50 of 24 μM. It significantly promotes platelet aggregation through ADP- and MMP-2-dependent pathways, demonstrating resistance to inhibition by Aspirin. Additionally, TRAP-14 amide enhances the surface expression of glycoprotein Ib and GPIIb/IIIa while facilitating ADP release, making it a valuable tool for research into platelet function and thrombus formation.
Product Information
Catalog NumA57548
FormulaC81H119N21O22
Molecular Weight1738.94
CAS Number141923-36-6
SequenceSer-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-NH2
Sequence shorteningSFLLRNPNDKYEPF-NH2
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CO)N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)CC(N)=O)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(=O)N4[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N)=O)=O)CCC4)CCC(O)=O)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCC2
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