TREK inhibitor-3 is a selective inhibitor of the TREK-1 channel, exhibiting an IC50 of 0.81 μM and demonstrating blood-brain barrier permeability. This compound exhibits neuroprotective properties, significantly reducing the apoptosis of cortical neurons in models of oxygen-glucose deprivation and reoxygenation, as well as improving outcomes in mouse models of ischemic stroke, specifically middle cerebral artery occlusion and reperfusion. TREK inhibitor-3 serves as a valuable tool for investigating ischemic stroke and related neuroprotective mechanisms.
TREK inhibitor-3 is a selective inhibitor of the TREK-1 channel, exhibiting an IC50 of 0.81 μM and demonstrating blood-brain barrier permeability. This compound exhibits neuroprotective properties, significantly reducing the apoptosis of cortical neurons in models of oxygen-glucose deprivation and reoxygenation, as well as improving outcomes in mouse models of ischemic stroke, specifically middle cerebral artery occlusion and reperfusion. TREK inhibitor-3 serves as a valuable tool for investigating ischemic stroke and related neuroprotective mechanisms.
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