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tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12)

Catalog No.: A64130
ASGPR Ligand
tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12) is a potent ligand for the asialoglycoprotein receptor (ASGPR), facilitating targeted delivery to lysosomes. This compound is specifically designed for applications in lysosome-targeting chimera (LYTAC) research, offering enhanced cellular uptake and improved therapeutic efficacy. Its unique structure enables effective receptor recognition and binding, making it a valuable tool for studying ASGPR-mediated pathways.
tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12) 3099288-71-5 ASGPR Ligand
Grouped product items
Size Price Stock Qty
500µg
$505.00
In stock
1mg
$800.00
In stock
5mg
$2,050.00
In stock
10mg
$3,360.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptiontri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12) is a potent ligand for the asialoglycoprotein receptor (ASGPR), facilitating targeted delivery to lysosomes. This compound is specifically designed for applications in lysosome-targeting chimera (LYTAC) research, offering enhanced cellular uptake and improved therapeutic efficacy. Its unique structure enables effective receptor recognition and binding, making it a valuable tool for studying ASGPR-mediated pathways.
Product Information
Catalog NumA64130
FormulaC152H236FN25O62S2
Molecular Weight3488.76
CAS Number3099288-71-5
SMILESO=C1N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CSSC[C@H](NC([C@H](CC(O)=O)NC(C)=O)=O)C(N[C@@H](C)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC(NCC4=CC(F)=C(OC(CCOCCOCCNC(CCOCCOCCOCCOCCC(NCC(NC(COCCC(NCCOCCOCCO[C@H]5[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O5)=O)(COCCC(NCCOCCOCCO[C@H]6[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O6)=O)COCCC(NCCOCCOCCO[C@H]7[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O7)=O)=O)=O)=O)=O)C=C4)=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H]1CC8=CNC9=CC=CC=C89)=O)=O)=O)=O)=O)=O)=O)=O)=O
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Endocrinology-Hormones > GPR