TRK-851 is a highly selective δ-opioid receptor antagonist, with a pA2 value of 8.84, indicating strong binding affinity. It exhibits over 100-fold selectivity for the δ-opioid receptor compared to μ or κ receptors. This compound demonstrates significant antitussive effects in preclinical models, particularly in capsaicin-induced cough assays. TRK-851 is suitable for research focused on the mechanisms of cough suppression and the role of δ-opioid receptors in pain modulation.
TRK-851 is a highly selective δ-opioid receptor antagonist, with a pA2 value of 8.84, indicating strong binding affinity. It exhibits over 100-fold selectivity for the δ-opioid receptor compared to μ or κ receptors. This compound demonstrates significant antitussive effects in preclinical models, particularly in capsaicin-induced cough assays. TRK-851 is suitable for research focused on the mechanisms of cough suppression and the role of δ-opioid receptors in pain modulation.
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