Troglitazone

Catalog No.: A11981

PPARγ agonist

Troglitazone

Troglitazone Chemical Structure

CAS NO. 97322-87-7

Troglitazone is a selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively).

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Package Price Qty
10 mg
$80.00
25 mg
$180.00
50 mg
$320.00
100 mg
$600.00
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  • Julien Allard, .et al. Drug-induced Hepatic Steatosis in Absence of Severe Mitochondrial Dysfunction in HepaRG Cells: Proof of Multiple Mechanism-Based Toxicity, Cell Biol Toxicol, 2020, Jun 14 PMID: 32535746

Biological Activity

Troglitazone is a selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively).
In vitro (25°C) DMSO Warmed: 85 mg/mL (192.51 mM)
Water Insoluble
Ethanol Warmed: 15 mg/mL (33.97 mM)
In vivo 1% CMC Na 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.65 mL 113.24 mL 226.48 mL
0.5 mM 4.53 mL 22.65 mL 45.3 mL
1 mM 2.26 mL 11.32 mL 22.65 mL
5 mM 0.45 mL 2.26 mL 4.53 mL

*The above data is based on the productmolecular weight 441.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11981
Actions Agonist
CAS No. 97322-87-7
Formula C24H27NO5S
M. Wt 441.54
Purity >98%
Synonyms Rezulin
SMILES CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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