TRR469 is a positive allosteric modulator of the A1 adenosine receptor (A1AR). It enhances the binding affinity of 2-chloro N(6)-cyclopentyladenosine (CCPA) for A1AR, thereby increasing the recognition of receptors by the agonist radioligand [³H]-CCPA. TRR469 demonstrates significant efficacy in preclinical models of anxiety and pain, making it a valuable tool for investigating anxiety disorders and developing pain management strategies.
TRR469 is a positive allosteric modulator of the A1 adenosine receptor (A1AR). It enhances the binding affinity of 2-chloro N(6)-cyclopentyladenosine (CCPA) for A1AR, thereby increasing the recognition of receptors by the agonist radioligand [³H]-CCPA. TRR469 demonstrates significant efficacy in preclinical models of anxiety and pain, making it a valuable tool for investigating anxiety disorders and developing pain management strategies.
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