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TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.
| In vitro | DMSO | 63 mg/mL (190.66 mM) | |
| Water | Insoluble | ||
| Ethanol | 8 mg/mL (24.21 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.26 mL | 151.32 mL | 302.65 mL |
| 0.5 mM | 6.05 mL | 30.26 mL | 60.53 mL |
| 1 mM | 3.03 mL | 15.13 mL | 30.26 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.05 mL |
*The above data is based on the productmolecular weight 330.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14101 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 329907-28-0 |
| Formula | C16H14N2O2S2 |
| M. Wt | 330.42 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | TTP 22, TTP22 |
| SMILES | CC1=CC=C(C=C1)C2=CSC3=C2C(=NC=N3)SCCC(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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