TUG-2181

Catalog No.: A39216
GPR84 Antagonist
TUG-2181 is a GPR84 antagonist, exhibiting an IC50 value of 34 nM. This compound effectively inhibits reactive oxygen species (ROS) production and interleukin-8 (IL-8) release in human neutrophils stimulated by GPR84 agonists. TUG-2181 is particularly valuable for research exploring the mechanisms of inflammation and fibrosis.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTUG-2181 is a GPR84 antagonist, exhibiting an IC50 value of 34 nM. This compound effectively inhibits reactive oxygen species (ROS) production and interleukin-8 (IL-8) release in human neutrophils stimulated by GPR84 agonists. TUG-2181 is particularly valuable for research exploring the mechanisms of inflammation and fibrosis.
Product Information
Catalog NumA39216
FormulaC21H27NO4
Molecular Weight357.44
CAS Number2653994-24-0
SMILESOC1=CC(CCC2=CC=C(C=C2)OCC)=NC(OCC3CCCCO3)=C1
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