Tyk2-IN-22-d3 is a deuterated analog of Tyk2-IN-22, specifically targeting tyrosine kinase 2 (Tyk2). This selective inhibitor demonstrates potent inhibition of Tyk2, JAK1, and JAK3, with IC50 values of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22-d3 effectively inhibits the downstream phosphorylation of STAT5, making it a valuable tool for research in signaling pathways and therapeutic development related to autoimmune diseases and cancers.
Tyk2-IN-22-d3 is a deuterated analog of Tyk2-IN-22, specifically targeting tyrosine kinase 2 (Tyk2). This selective inhibitor demonstrates potent inhibition of Tyk2, JAK1, and JAK3, with IC50 values of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22-d3 effectively inhibits the downstream phosphorylation of STAT5, making it a valuable tool for research in signaling pathways and therapeutic development related to autoimmune diseases and cancers.
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