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Tyk2-IN-22-d3

Tyk2-IN-22 Isotopes

Tyk2-IN-22-d3 is a deuterated analog of Tyk2-IN-22, specifically targeting tyrosine kinase 2 (Tyk2). This selective inhibitor demonstrates potent inhibition of Tyk2, JAK1, and JAK3, with IC50 values of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22-d3 effectively inhibits the downstream phosphorylation of STAT5, making it a valuable tool for research in signaling pathways and therapeutic development related to autoimmune diseases and cancers.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1771691-32-7
Applications	Tyk2-IN-22 Isotopes
Formula	C₂₀H₁₉D₃N₈O₃
Molecular Weight	425.46
SMILES	COC1=C(C2=NN(C)N=N2)C=CC=C1NC3=CC(NC(C4CC4)=O)=NC=C3C(NC([2H])([2H])[2H])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.