Type II TRK inhibitor 1 is a selective inhibitor targeting TRK fusion proteins and wild-type TRK, demonstrating potent anti-proliferative effects in Ba/F3 cell lines that express the CD74-TRKAG667C and ETV6-TRKCG696C variants, with IC50 values of 6 nM and 1.7 nM, respectively. Additionally, this compound functions as a click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling its application in bioconjugation and related chemical biology research.
Type II TRK inhibitor 1 is a selective inhibitor targeting TRK fusion proteins and wild-type TRK, demonstrating potent anti-proliferative effects in Ba/F3 cell lines that express the CD74-TRKAG667C and ETV6-TRKCG696C variants, with IC50 values of 6 nM and 1.7 nM, respectively. Additionally, this compound functions as a click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling its application in bioconjugation and related chemical biology research.
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