Tyrosine kinase-IN-7 is a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It exhibits inhibitory activity with IC50 values of 0.630 μM for EGFR wild-type and 0.956 μM for the T790M mutant variant. Tyrosine kinase-IN-7 demonstrates significant antitumor effects across several cancer cell lines, including HepG2, HCT-116, MCF-7, and A431, with respective IC50 values of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM. This compound is useful for research focused on cancer therapeutics targeting the EGFR signaling pathway.
Tyrosine kinase-IN-7 is a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It exhibits inhibitory activity with IC50 values of 0.630 μM for EGFR wild-type and 0.956 μM for the T790M mutant variant. Tyrosine kinase-IN-7 demonstrates significant antitumor effects across several cancer cell lines, including HepG2, HCT-116, MCF-7, and A431, with respective IC50 values of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM. This compound is useful for research focused on cancer therapeutics targeting the EGFR signaling pathway.
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