Tyrphostin AG1112 is a potent inhibitor of casein kinase II (CK II). It demonstrates notable inhibition of the p210bcr-abl tyrosine kinase, with IC50 values of 2 μM for p210bcr-abl, 15 μM for epidermal growth factor receptor (EGFR), and 20 μM for platelet-derived growth factor receptor (PDGFR) in relevant cellular models. This compound is valuable for research investigating cancer signaling pathways and therapeutic interventions targeting kinase activity.
Tyrphostin AG1112 is a potent inhibitor of casein kinase II (CK II). It demonstrates notable inhibition of the p210bcr-abl tyrosine kinase, with IC50 values of 2 μM for p210bcr-abl, 15 μM for epidermal growth factor receptor (EGFR), and 20 μM for platelet-derived growth factor receptor (PDGFR) in relevant cellular models. This compound is valuable for research investigating cancer signaling pathways and therapeutic interventions targeting kinase activity.
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