TZD18 is a potent dual agonist of PPARα and PPARγ, exhibiting IC50 values of 0.028 µM and 0.057 µM, respectively, while showing minimal activity toward PPARδ (>10 µM). This compound effectively reduces plasma glucose and triglyceride levels in diabetic mouse models. TZD18 holds promise for research into type 2 diabetes and related metabolic disorders.
TZD18 is a potent dual agonist of PPARα and PPARγ, exhibiting IC50 values of 0.028 µM and 0.057 µM, respectively, while showing minimal activity toward PPARδ (>10 µM). This compound effectively reduces plasma glucose and triglyceride levels in diabetic mouse models. TZD18 holds promise for research into type 2 diabetes and related metabolic disorders.
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