U-104

Catalog No.: A14959

Carbonic anhydrase (CA) inhibitor

U-104

U-104 Chemical Structure

CAS NO. 178606-66-1

U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX).

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Package Price Qty
10 mg
$45.00
25 mg
$95.00
50 mg
$175.00
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Biological Activity

U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX).
Targets
CAXII CAIX CAI CAII
4.5 nM(Ki)45.1 nM(Ki)5.08 μM(Ki)9.64 μM(Ki)
In vitro (25°C) DMSO 60 mg/mL (193.96 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.33 mL 161.64 mL 323.29 mL
0.5 mM 6.47 mL 32.33 mL 64.66 mL
1 mM 3.23 mL 16.16 mL 32.33 mL
5 mM 0.65 mL 3.23 mL 6.47 mL

*The above data is based on the productmolecular weight 309.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14959
Actions Inhibitor
CAS No. 178606-66-1
Formula C13H12FN3O3S
M. Wt 309.32
Solubility DMSO
Purity >98%
Synonyms NSC 213841, U 104, U104
SMILES C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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