UK 357903 is a selective inhibitor of phosphodiesterase 5 (PDE5), exhibiting IC50 values of 1.7 nM for PDE5 and 714 nM for PDE6. This compound demonstrates significant vasodilatory effects in mesenteric and hindlimb vascular beds, making it a promising candidate for research applications related to erectile dysfunction and vascular smooth muscle relaxation. Its mechanism of action provides a valuable tool for investigating PDE5-related pathways in various physiological and pathological contexts.
UK 357903 is a selective inhibitor of phosphodiesterase 5 (PDE5), exhibiting IC50 values of 1.7 nM for PDE5 and 714 nM for PDE6. This compound demonstrates significant vasodilatory effects in mesenteric and hindlimb vascular beds, making it a promising candidate for research applications related to erectile dysfunction and vascular smooth muscle relaxation. Its mechanism of action provides a valuable tool for investigating PDE5-related pathways in various physiological and pathological contexts.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
