UK-500001 is a selective inhibitor of phosphodiesterase 4 (PDE4), demonstrating high potency with IC50 values of 0.28 nM for PDE4D3, 22.8 nM for PDE4B2, 26.1 nM for PDE4A4, and 271 nM for PDE4C2. This compound exhibits significant anti-inflammatory properties by effectively inhibiting the release of TNF-α and IFN-γ in both human and rodent macrophagic cell lines at nanomolar concentrations. UK-500001 holds potential for research applications in chronic obstructive pulmonary disease (COPD) and asthma treatment.
UK-500001 is a selective inhibitor of phosphodiesterase 4 (PDE4), demonstrating high potency with IC50 values of 0.28 nM for PDE4D3, 22.8 nM for PDE4B2, 26.1 nM for PDE4A4, and 271 nM for PDE4C2. This compound exhibits significant anti-inflammatory properties by effectively inhibiting the release of TNF-α and IFN-γ in both human and rodent macrophagic cell lines at nanomolar concentrations. UK-500001 holds potential for research applications in chronic obstructive pulmonary disease (COPD) and asthma treatment.
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