UNC-1999

Catalog No.: A13166

EZH2/EZH1 Inhibitor

UNC-1999

UNC-1999 Chemical Structure

CAS NO. 1431612-23-5

UNC1999 is the first orally bioavailable inhibitor that has high in vitro potency for wildtype and mutant EZH2 as well as EZH1.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $54.00

10 mg

Regular Price: $110.00

Special Price $99.00

25 mg

Regular Price: $220.00

Special Price $198.00

50 mg

Regular Price: $350.00

Special Price $315.00

10mM * 1mL in DMSO

Regular Price: $127.00

Special Price $114.30

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

UNC1999 is the first orally bioavailable inhibitor that has high in vitro potency for wildtype and mutant EZH2 as well as EZH1.
Targets
EZH2 (Cell-free assay) EZH1 (Cell-free assay)
2 nM45 nM
In vitro DMSO 100 mg/mL (175.51 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (175.51 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.55 mL 87.76 mL 175.52 mL
0.5 mM 3.51 mL 17.55 mL 35.1 mL
1 mM 1.76 mL 8.78 mL 17.55 mL
5 mM 0.35 mL 1.76 mL 3.51 mL

*The above data is based on the productmolecular weight 569.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13166
Actions Inhibitor
M. Wt 569.74
Formula C33H43N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1431612-23-5
Synonyms UNC 1999, UNC1999
SMILES CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C

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