UNC0642

Catalog No.: A15487

G9a/GLP inhibitor

UNC0642

UNC0642 Chemical Structure

CAS NO. 1481677-78-4

UNC0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5 nM). It reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM). Displays modest brain penetration in vivo.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $150.00

Special Price $135.00

25 mg

Regular Price: $300.00

Special Price $270.00

50 mg

Regular Price: $450.00

Special Price $405.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

UNC0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5 nM). It reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM). Displays modest brain penetration in vivo.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.29 mL 91.46 mL 182.92 mL
0.5 mM 3.66 mL 18.29 mL 36.58 mL
1 mM 1.83 mL 9.15 mL 18.29 mL
5 mM 0.37 mL 1.83 mL 3.66 mL

*The above data is based on the productmolecular weight 546.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A15487
Actions Inhibitor
M. Wt 546.69
Formula C29H44F2N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1481677-78-4
Synonyms UNC 0642, UNC-0642
SMILES CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F

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