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Vandetanib-13C6

Stable Isotope

Vandetanib-13C6 is a stable carbon isotope-labeled form of Vandetanib, which serves as a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity with an IC50 of 40 nM. In addition, it effectively inhibits the tyrosine kinase activity of VEGFR3/FLT4 (IC50 of 110 nM) and EGFR/HER1 (IC50 of 500 nM). This reagent is valuable for biological research applications involving cancer signaling pathways, pharmacokinetics, and biomarker studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1261397-03-8
Applications	Stable Isotope
Formula	C₁₆₁₃C₆H₂₄BrFN₄O₂
Molecular Weight	481.31
Synonyms	ZD6474-13C6
SMILES	CN(CC1)CCC1COC(C(OC)=C2)=CC3=C2C(N[13C]4=[13C]([13CH]=[13C]([13CH]=[13CH]4)Br)F)=NC=N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.